Endocrine Abstracts

Adiponectin (ADPN), resistin (RSN) and leptin are proteins that affect insulin resistance and atherosclerosis significantly. Although low levels of adiponectin and high levels of resistin and leptin are associated with coronary heart disease and cardiovascular disease risk factors, it is unclear whether adiponectin, resistin and leptin levels are related to the risk of developing ischemic stroke. The aim of the study was to evaluate the adiponectin, resistin and leptin serum l...

Autoimmune thyroiditis (AIT) is characterised by infiltration of the thyroid by lymphocytes and other immune cells. Autoantibodies to thyroid-specific antigens: thyroglobulin (TG) and thyroperoxidase (TPO) are also produced. The penetration of inflammatory cells into target organ is regulated by cytokines and adhesion molecules expressed on thyroid endothelial cells. E-selectin is one of the selectin family, and is responsible for interaction between leukocytes and endothelium...

Background: Thyroid hormone deficiency is associated with increased cardiovascular morbidity, which cannot be fully explained by the atherogenic changes in lipid profile observed in these patients. Hyperhomocysteinemia could help to explain the increased risk for arteriosclerotic coronary artery disease in hypothyroidism because is an important and independent risk factor for cardiovascular disease. Hypothyroidism decreases hepatic levels of enzymes involved in the remethylati...